ABSTRACT
AIM: To observe the macular retina vascular density of patients with acute central retinal artery occlusion(CRAO)by optical coherence tomography angiography(OCTA)and to analyze the relationship with retinal circulation time of these patients on fundus fluorescein angiography(FFA).METHODS: Retrospective case analysis. A total of 43 patients(43 eyes)from January 2019 to March 2021 admitted to Shaanxi Eye Hospital with clinical diagnosis of acute CRAO(course of disease ≤7d)were included. All patients underwent FFA, OCTA, best corrected visual acuity(BCVA)examination and thrombolytic therapy. The patients with enhanced or unchanged retinal blood flow signal in the affected eye showed on OCTA before treatment compared with the contralateral healthy eye were assigned to group A, and the patients with retinal blood flow signal of the affected eye was lower than that in the contralateral healthy eye by OCTA were assigned to group B. Image J software was used for OCTA image processing to evaluate the macular retina vascular density before treatment, and FFA examination was performed to record the affected retinal circulation time before treatment.RESULTS: The retinal vascular density of patients in the affected eye and the contralateral healthy eye in group A was higher than that in group B(25.08%±4.40% vs 12.24%±3.41%, 25.72%±2.70% vs 17.89%±4.55%, all P<0.001), the filling time(FT)of retinal artery trunk to terminal in group B [96(20.50, 193.50)s] was longer than that in group A [11(5.00, 19.50)s](P<0.001). The course of disease, the retinal vascular density of contralateral healthy eye and FT were related factors of retinal vascular density of the affected eye(all P<0.05), and the influence strength order was FT, course of disease and the retinal vascular density of contralateral healthy eye, in which the course of disease and FT was negatively correlated with the retinal vascular density.CONCLUSION: OCTA retinal vascular density was correlated with FFA retinal circulation time in CRAO patients.
ABSTRACT
The aim was to investigate the relationships among lean mass [LM], fat mass [FM], and bone mineral density [BMD] in women stratified by body mass index [BMI] [BMI - normal-weight, overweight, obese] and to determine threshold at which body fat assumes negative relationship with BMD. This was a cross-sectional study in 471 healthy Caucasian women, aged 18-67 years. BMD, LM, and FM were measured using dual-energy X-ray absorptiometry. Analysis of variance with Bonferroni corrections was used to test the BMI group differences. Linear regression was used to examine independent contributions of LM and FM on BMD of various skeletal sites [controlling for age and height]. In overweight/obese women PROC LOESS plots were used to determine the inflection points at which either LM or FM relationship with BMD changes direction. Separate analyses in pre- and post-menopausal women were conducted as well. Spine and femoral neck BMD were not different among three BMI groups while total body, femur and radius BMD were statistically different [the highest in the obese group]. Linear regression revealed that LM had significant positive association with BMD of various skeletal sites in all groups. FM showed a negative association with BMD of femoral neck and femur in normal-weight and spine in overweight women, but a positive association with radius in obese women. Inflection points showed that body fat between 33% and 38% assumed negative relationship with BMD for most skeletal sites in overweight and obese women. Although LM has strong positive relationship with BMD, FM above 33% in overweight/obese women is negatively related to BMD of most skeletal sites. Therefore, overweight/obesity after certain amount of FM, may not be a protective factor against osteoporosis in females. For clinical practice in women, it is important to maintain LM and keep FM accrual below 30% body fat to maintain good skeletal health